@article{16048,
  author = {C{\'e}cile Daversin-Catty and Vegard Vinje and Kent-Andre Mardal and Marie Rognes},
  title = {The mechanisms behind perivascular fluid flow},
  abstract = {Flow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscillatory particle movement has a clear cardiac component, while the mechanisms involved in net movement remain disputed. Using computational fluid dynamics, we computed the CSF velocity and pressure in a PVS surrounding a cerebral artery subject to different forces, representing arterial wall expansion, systemic CSF pressure changes and rigid motions of the artery. The arterial wall expansion generated velocity amplitudes of 60{\textendash}260 μm/s, which is in the upper range of previously observed values. In the absence of a static pressure gradient, predicted net flow velocities were small (\},
  year = {2020},
  journal = {PLOS ONE},
  volume = {15},
  number = {12},
  pages = {1-20},
  publisher = {Public Library of Science},
  url = {https://doi.org/10.1371/journal.pone.0244442},
  doi = {10.1371/journal.pone.0244442},
}