@article{17706,
  author = {Nathaniel Herrera and Xianwei Zhang and Haibo Ni and Molly Maleckar and Jordi Heijman and Dobromir Dobrev and Eleonora Grandi and Stefano Morotti},
  title = {Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study},
  abstract = {By sensing changes in intracellular Ca2+, small-conductance Ca2+-activated K+ (SK) channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to-beat basis. Given their predominance in atria versus ventricles, SK channels are considered a promising atrial-selective pharmacological target against atrial fibrillation (AF), the most common cardiac arrhythmia. However, the precise contribution of SK current (ISK) to atrial arrhythmogenesis is poorly understood, and may potentially involve different mechanisms that depend on species, heart rates, and degree of AF-induced atrial remodeling. Both reduced and enhanced ISK have been linked to AF. Similarly, both SK channel up- and downregulation have been reported in chronic AF (cAF) versus normal sinus rhythm (nSR) patient samples. Here, we use our multiscale modeling framework to obtain mechanistic insights into the {\textellipsis}},
  year = {2023},
  journal = {American Journal of Physiology-Heart and Circulatory Physiology},
  volume = {325},
  pages = {H896-H908},
  publisher = {American Physiological Society},
}