@misc{17707,
  author = {{\r A}shild Telle and Molly Maleckar and Joakim Sundnes and Samuel Wall and Patrick Boyle},
  title = {Contractility and Local Stress Patterns Depend on Directionality of Fibrosis Progression: Insights From Microscale Biomechanical Simulations},
  abstract = {Introduction: Cardiac fibrosis, a common pathological process in heart disease, leads to reduced contractility and increased myocardial stiffness. However, it remains unclear how various cellular and subcellular events individually contribute to these changes.

Hypothesis: Tissue-scale biomechanical effects resulting from cellular and subcellular changes, such as myocyte loss and increased ECM stiffness, are anisotropic and depend on the prevailing direction of fibrosis progression.

Methods: We used a mechanical modeling framework allowing for explicit geometrical representation of individual myocytes embedded in ECM. We used a transversely isotropic hyperelastic formulation for the cells while assuming the ECM to be isotropic. Contraction was imposed in each cell using an active stress model.

In a simulated tissue domain (6х12 cells), we explored different cellular configurations (Fig. 1A) representing {\textellipsis}},
  year = {2023},
  journal = {Circulation Supplement},
  month = {11/2023},
  publisher = {Lippincott Williams \& Wilkins},
  address = {Circulation Supplement; American Heart Association Annual Meeting},
}